Gestational diabetes is defined as glucose intolerance that is identified, for the first time, during pregnancy and occurs at 3% to 13% of all pregnant women, and increases the risk, for women, to develop diabetesType 2 in 20% to 50% within five years after pregnancy.
has discovered a new, simple, exact form, to predict which women with gestational diabetes, they will develop type 2 diabetes, after childbirth , which will allow health care providers, identifywomen with greater risk and help motivate women to make changes in early lifestyle and follow other strategies that could prevent them from developing the disease later in life.
An international team of scientists who worked with those of the University of Toronto (ON, Canada) obtained blood samples of 1,035 women diagnosed with gestational diabetes and enrolled in women's studies, child feeding and type 2 diabetes of KaiserPermanent, after a pregnancy with gestational diabetes, also known as the Swift study.
The Swift studio examined women through oral tolerance tests at two months, after childbirth, and then every year, in order to evaluate the impact of breastfeeding and other characteristics on the development of type diabetes2 After a pregnancy complicated by gestational diabetes.
The team carried out a metabolomic study in basal fasting plasma, and identified 21 metabolites that differed significantly due to the incidental state of type 2 diabetes (DM2).
Optimization by automatic learning resulted in a model in the form of a decision tree that predicted the incidence of type 2 diabetes, with a discrimination power of 83.0% in the training set and 76.9%, in the setof independent tests, being much superior to the plasma glucose on an empty stomach, alone.
The new method may also be able to predict individuals who can develop type 2 diabetes in the general population which would be an important advance at a time when more than 300 million people suffer in the preventable way of this disease.
A next -generation blood analysis, which is easier and more exact that current options could help identify the people who would benefit most from the most appropriate and effective interventions to prevent type 2 diabetes.
Michael B. Wheeler, PHD, a professor in the Department of Physiology and main author of the study, said: “After delivery, many women are very difficult to program two hours for another glucose test.What if we could create a much more effective test that women could be practiced while they are still in the hospital?Once diabetes has been developed, it is very difficult to reverse. ”The study was published in the June 2016 edition of Diabetes magazine.
