Type 2 diabetes is a chronic disease that is increasing worldwide, especially in the so -called developing countries.World experts talk about an epidemic of diabetes: cases have quadupplicated, from 108 million in 1980 to 422 in 2014, half of which live in China, India, USA, UU., Brazil and Indonesia.
bacteria, coagulation and diabetes
The world health emergency that diabetes supposes requires investigating its causative mechanisms to be able to develop new drugs and treatments to combat it.One of these research paths is the possible bacterial origin of the disease.Like other inflammatory diseases such as Alzheimer's, Parkinson's or rheumatoid arthritis, the role of bacteria in type 2 diabetes is being investigated.
Researchers from Stellenbosch (South Africa) and Manchester (United Kingdom) universities have studied the role of diabetes bacteria.Bacteria, contrary to what was thought until recently, are present in human blood, but latent, hence the standard laboratory tests do not detect them.The presence of bacteria would explain the increase in lipopolysaccharides (LPS) in the blood, causing inflammation.High blood levels associated with inflammatory diseases could "arouse" these bacteria, causing them to begin to replicate and secrete LPS, increasing inflammation and causing an anomalous coagulation mechanism identified in Alzheimer's and now also in type 2 diabetes.
The authors of the aforementioned study had already established in previous works that the anomalous coagulation of amyloidogenic blood causes inflammation associated with cell death and neuronal degeneration.Since coagulopathies are a characteristic aspect of type 2 diabetes, researchers raised if they could also be caused by LPS.The new study states that the blood clots of type 2 diabetes patients also have this same structural anomaly.
In order to determine the relationship between these clots, bacteria and LPS, scientists investigated the effect of LPS union protein (called LBP protein) that is produced by the organism.By adding LBP to the blood of patients with type 2 diabetes, it was seen that the formation of abnormal blood clots of type 2 diabetes patients could be reversed, demonstrating that coagulopathies are an important characteristic of type 2 diabetes and that could be causedBy "hidden" LPS, which would be an important element in the development and maintenance of type 2 diabetes, and therefore a possible new way to investigate both for prevention and for the treatment of diabetes.
Diabetes
According to the World Health Organization (WHO), in 2012 this disease was the direct cause of approximately 1.5 million deaths, of which more than 80% occurred in poor countries.According to WHO forecasts, diabetes will be the seventh cause of death by 2030.
Diabetes is a chronic disease that occurs when the pancreas does not produce enough insulin, or when the body cannot effectively use the insulin it produces.Insulin, a hormone that regulates blood sugar, gives us the energy necessary to live.If you cannot reach the cells to become energy, sugar accumulates in the blood until reaching harmful levels.
There are two main forms of diabetes.People with type 1 diabetes generally do not produce insulin, so they need insulin injections to survive.People with type 2 diabetes, who represent 90% of cases, usually produce their own insulin, but the amount is insufficient or cannotuse properly;They are usually overweight and are sedentary, two circumstances that increase their insulin needs.
Over time, hyperglycemia can endanger all the main organs of the body and cause heart attacks, stroke, neuropathies, renal failure, blindness, helplessness and infections that amputation may need.
