Researchers from the Technological University of Chalmers (United States) have discovered certain differences in the functioning of exosomes, small structures secreted by cells to favor intercellular communication, which can be key to the treatment of type 2 diabetes.
Specifically, as described in an article published in the Journal Proceedings of the National Academy of Sciences (PNAS), they have seen that in healthy people these particles avoid the accumulation of a key protein in the appearance of type 2 diabetes but, inChange does not have the same capacity when the disease is already present.
Proteins are the body's battle horses, carry out all the tasks of our cells, and are formed by a long chain of amino acids that must be folded in a specific three -dimensional structure to function.
But sometimes they behave incorrectly and grouped into long fibers called amyloids, which can cause certain diseases.In this way, previous studies had found that type 2 diabetes is caused by a protein that accumulates in the pancreas.
"What we have discovered now is that the exosomes secreted by pancreas cells stop this process in healthof this study carried out in collaboration with Astrazeneca.
These healthy exosomes bind to the protein that causes diabetes abroad, preventing it from being added.However, the results do not explain why.
"We do not know if type 2 diabetes is caused by" sick "exosomes or if the disease itself causes malfunction. Given this situation, the next step is to make controlled models of exosomes whose membranes contain lipids and proteins, to understandExactly what component influences the diabetes protein.The doctor pointed out.
