Patients who took metformin, the most common medication were the most likely to stop taking the dose.
According to public Health England 3.8 million people in the United Kingdom suffer from diabetes, and approximately 90% of cases this are type 2, formerly called non -insulin -dependent diabetes or adult, caused by the low use of insulinand related to excess weight and physical inactivity.
According to the World Health Organization, WHO, in 2012 this evil caused 1.5 million deaths worldwide and those affected by this disease increased from 108 million in 1980 to 422 million in 2014. Now, a meta -analysis published in theDiabetes Magazine, Obesity and Metabolism states that a third of patients abandon treatment due to their side effects.
Researchers at the University of Surrey (United Kingdom) examined in detail the adherence to the treatment of 1.6 million people with type 2 diabetes.
The study combined clinical trial data and observational studies and analyzed therapies with pills and injectable medications.The researchers discovered that those who took metformin, the most common medication, were the most likely to stop taking the required doses, specifically 30%, compared to other diabetes medications: 23% abandonment rate of sulfonylureas (such as glyclazide) and 20% of the pioglitazone.
For their part, DPP4 (gliptinas) inhibitors, one of the newest medicines classes, have the highest adhesion rates, with only 10% to 20% of the non -taken medication doses.When comparing injectable medications, it was found that patients have twice as probabilities to stop taking the agonists of the LPG1 receiver (as exenatted) compared to insulin.
Researchers believe that lack of compliance is due in part to the side effects of different medications: metformin normally causes gastrointestinal symptoms such as diarrhea and flatulence, while DPP4 inhibitors are generally better tolerated by the body.
It is also believed that it may have to do that for some medications it is necessary to take multiple daily doses.For Andy McGovern, clinical researcher at the University of Surrey, "the importance of diabetes patients taking their prescription medications cannot be underestimated. If they do not, they can cause complications in their condition, including eye diseases and renal damage."
Scientists encourage that the inconveniences that patients find in prescription medications, whether it is side effects or schedules difficult to meet, to comment openly with health professionals.They remember that for type 2 diabetes there are many treatment options and changing to a different class of medications that are easier to take could provide an easy way to improve adhesion.On the other hand, they encourage doctors and nurses to actively ask their patients about adherence to medicines.
Diabetes is a chronic disease, which occurs in the pancreas when it does not produce enough insulin (a hormone that allows the body to obtain energy from sugar) or when the organism does not take advantage of it sufficiently.
This leads to a greater concentration of glucose (sugar) in the blood (hyperglycemia).Although current therapies to keep evil at the same time focus on administering drugs that regulate blood glucose levels, few have focused their work on elucidating bacteria in this inflammatory disease.
A team of researchers from Stellenbosch universities (South Africa) and Manchester (United Kingdom), said in an article published in August:"Now we have a considerable amount of tests, many of them new, which unlike the current strategies to attack type 2 diabetes, involve the recognition of latent microbes, chronic inflammatory processes and coagulopathies, offering new opportunities for treatment."
