Study confirms the cognitive damage that diabetic ketoacidosis has in children with diabetes

Because we must avoid ketoacidosis in children with diabetes.

Even a single episode of diabetic ketoacidosis in school -age children can have a lasting effect on cognitive function, according to a recent study.

Diabetic ketoacidosis is the most common acute cause of morbidity and mortality in children with type 1 diabetes. Ketoacidosis (CAD) has structural acute effects on the brain and has been associated with long -term adverse cognitive effects according to an investigation recently published in theDiabetes Care Magazine.

The researchers examined the data of 144 children aged 4 to 9 who participated in an observational study.Everyone had unredested magnetic resonance and cognitive evidence at the beginning of the study and 18 months later.

The children were initially divided into two groups.In one of them there had been specific episodes of ketoacidosis, and in the other not.No participant experienced more than one CAD episode, and all but four experienced their episode of diabetic body in the diagnosis of diabetes.These four were excluded from the analysis

In general, the moderate / severe group won more total and regional white and gray matter volume during the observed 18 months compared to the non / mild group.

To examine the specific effect of the severity of ketoacidosis, the team compared a subgroup of 30 participants matched by age at the beginning of the study and exposure of blood glucose that experienced an episode of mild diabetic ketoacidosis, with the 30 participants who experienced an episodeModerate / severe of ketoacidosis.

The differences in yield in cognitive scores in the follow -up "became more prominent in relation to the total sample, despite the smallest sample size," according to the team.

According to the director of the study, Dr. Aye, ”A history of moderate or severe ketoacidosis in children can have an impact on the lasting neurocognitive function after the episode.”"More studies are needed that take into account the severity of ketoacidosis," he added.Researchers also point out that more research is needed “to determine whether the early diagnosis of type 1 diabetes and ketoacidosis prevention can reduce the long -term effect of ketoacidosis on the developing brain.”