Chewable capsule to administer insulin?

It seems science fiction, but it is closer than we imagine. A team of the Massachusetts Institute of Technology (MIT) has developed a chewable capsule that could be used to administer insulin dose, which could replace the injections that people with diabetesType 2 must be administered every day.

Of a size similar to a blueberry, the capsule contains a small needle made of compressed insulin, which is activated once the capsule reaches the stomach.In animals, the researchers showed that they could administer sufficient insulin to reduce blood sugar to levels comparable to those produced by traditional injections, administered through the skin.They have also seen that the device can be adapted to supply other drugs.

"We have a lot of hope that this new type of capsule can help diabetic patients and, it is possible, that to anyone who requires therapies that can now only be administered by injection or infusion," says Robert Langer, of in Stituto David H.Koch, and one of the main authors of the study published in the magazine «Science».

Several years ago, Langer together with the Giovanni Traverso group, of the Brigham and Women's Hospital and the Harvard Medical School (USA) developed a pill covered with multiple small needles that could be used to inject medications in the stomach or intestineslim.

On this occasion, the researchers changed the design to provide it with a single needle, which allows them to inject medications inside the stomach, where stomach acids would decompose them before having any effect.
The point of the needle is made of lyophilized and compressed insulin, and the same process used to form the drugs has been used.The needle axis, which does not enter the stomach wall, is made of other biodegradable material.

The researchers explain that the needle is linked to a compressed spring that is maintained thanks to an album made of sugar.When the capsule is ingested, the water in the stomach dissolves the sugar disc, releasing the spring and injecting the needle into the stomach wall.

Because the stomach wall has no pain receptors, scientists believe that patients could not feel injection.To ensure that the medicine is injected exactly into the stomach wall, they designed their system so that, regardless of how the capsule falls into the stomach, it can be oriented so that the needle is in contact with the coating of it.

In pigs in pigs, the researchers showed that they could successfully administer up to 300 insulin micrograms.And, recently, they have been able to increase the dose to 5 milligrams, comparable to the amount that a patient with type 2 diabetes would need.

After the capsule releases its content, it can pass harmlessly through the digestive system.The researchers did not find adverse effects of the capsule, which is made of biodegradable polymers and stainless steel components.

The MIT team continues to work with Novo Nordisk to further develop technology and optimize the capsules manufacturing process.They believe that this type of drug administration could be useful for any protein drug that should normally be injected, such as immunosuppressants used to treat rheumatoid arthritis or intestinal inflammatory disease.

Pfff that do not spend so much time or means on that.The puncture is the least.An intelligent insulin or an artificial pancreas, or simply a small and safe continuous meter.

Totally agree, everything that is to improve monitoring goes ahead of the rest ... :)

A smart bomb, in which you do not have to make ch.Just eat what you want and that the pump automatically manages the amount of insulin according to what you eat, to do the relevant corrections of blood glucose automatically in conjunction with a reliable continuous glucose monitor and therefore keep you in a range without problems, that isMy dream.It would be as the "true artificial pancreas" a dream that hopefully one day comes true.

Let's see if we are a bit more understanding, I, being of type 2 punctured me 5 times a day and took my purple stomach, since when a capillary Jose Pillas.
The one who carries a bomb, apart from its safety, only the canula has to be put once, and those of the ball apart from being able to make a slow and fast (my case) inherit the punctures.
Welcome capsule

wjjpn said:
to see if we are a little more understanding, I, being of type 2 punctured me 5 times a day and carried the purple stomach, since when a capillary Jose pillas.
The one who carries a bomb, apart from its safety, only the canula has to be put once, and those of the ball apart from being able to make a slow and fast (my case) inherit the punctures.
Welcome capsule

That attack the root cause and that our pancreas produces insulin as before being diabetic.
That seek the origin of this immunology that we suffer from the Mellitus diabetics.
So many years of study only to find palliatives.

@Jmjpn changes zone, arms and side of the waist.Ask for 6mm or less needles.If you click only on the abdomen they will necrose

In the buttock, for the slow, there is a lot of place too.

There is not what I want very far:#

This Tuesday, after the successful clinical tests, it had its official presentation.Its name is Arg -Automatic Regulation of Glucose -, an algorithm that commands the insulin infusion pump in people with type 1 diabetes.

During their first phase, in 2016, it required that the patient calculated and recorded in the system how many grams of carbohydrates would eat for the pump to unfound the necessary insulin.

Already in a second phase, in 2017, precise only that the start of the food is registered, without the need to calculate how many grams of carbohydrates will consume.
Your goal is to automatically regulate the value of blood sugar, without the need for the patient to make the usual insulin corrections in the management of type 1 diabetes.

https: //laopinion-digital.com/ultimas-noticias/como-funciona-el-pancreas-artificial-creado-por-argentinos/16-05-2019

ruthbia said:
that attack the root cause and that our pancreas produces insulin as before being diabetic.
That seek the origin of this immunology that we suffer from the Mellitus diabetics.
So many years of study only to find palliatives.

sherpa41 said:

Exactly, it is a real shame.Soon he will do 100 years of the discovery of insulin and continue with the same shit of therapy.Make some real advance or leave us alone.

The years go by and the light is not seen, the panorama is bleak.It seems that all efforts are overturned in apparatus to become half robots.

Our immune system works "well", except for the small problem that identifies our insulin producing cells as enemies.The theme of repopulating our body of these cells is quite advanced, but to fix the immune system so that they do not load them again, continue in diapers ...

I had hopes in the VC-01 (PEC-Encap) of Viacyte, that for practical purposes it would be a "cure" that would make the Apaño to the royal cure ... but they have seen that they are going for long and have focused on the pec-Direct, who has no protection against the immune system and should be taken immudrects, killing flies to cannon.

ruthbia said:
that attack the root cause and that our pancreas produces insulin as before being diabetic.
That seek the origin of this immunology that we suffer from the Mellitus diabetics.
So many years of study only to find palliatives.

@Jmjpn changes zone, arms and side of the waist.Ask for 6mm or less needles.If you click on the abdomen, they will necrose

So many years of study only to find palliatives = monetary benefits

It seems to me a fairly important scientific advance is a prick daily, it is quite unpleasant.Alfredo from Venezuela.

What I don't understand is what it says chewable.Reading the text seems rather a huge capsule that must be swallowed with a lot of difficulty to reach the intact stomach.