They create a new ultra -granted action insulin (4 times more than the rapid)
12/06/2023 10:09 a.m.
Researchers at Stanford University (United States) are developing a new formulation of fast -acting insulin: it begins to take effect almost immediately and could work four times faster than current insulins.
Based on monomeric insulin, a rapid action type, researchers decided to focus on trying to alleviate one of their main inconveniences: it is too unstable for practical use.
"The insulin molecules themselves are fine, so we wanted to develop a 'magical dust' that would help solve the stability problem," explains Eric Appel, assistant professor of material science and engineering at Stanford University.
"People often focus on therapeutic agents on the formulation of a medication, but, by focusing only on performance additives (parts that once referred as 'inactive ingredients') we can make great advances in the general effectiveness of thedrug".
After examining and testing a large number of additive polymers, the researchers found one that could stabilize monomeric insulin for more than 24 hours in stress conditions (fast -acting commercial insulin remains stable from six to ten hours in the same conditions).
"This has been an important objective for many large pharmaceutical companies for decades"
The researchers confirmed the ultra -grape action of their formulation in diabetic pigs and are now carrying out additional tests in the hope of being able to carry out clinical trials in humans.
The current commercial formulations of insulin contain a mixture of three ways: monomers, diameters and hexamers.Scientists have meant that monomers would be the most useful in the body but, inside the jars, insulin molecules are attracted to the surface of the liquid where they are added and becomes inactive.(Hexamers are more stable in the bottle but take longer to function in the body because they first have to break down in monomers to activate).This is where the personalized polymer that is attracted by the air/water interface enters.
In commercial insulin, which usually remains stable for about 10 hours in accelerated aging tests, the polymer drastically increased the duration of stability for more than a month.
The next step was to see how the polymer affected monomeric insulin, which alone joins between one and two hours.The researchers confirmed that their formulation could remain stable for more than 24 hours under stress.
"In terms of stability, we took a great step back when making monomeric insulin. Then, adding our polymer, we achieved more than double the stability of the current commercial standard," says Caitlin Maikawa, co -author of the study, which is published in theScientific Magazine 'Science Translational Medicine'.
Start and finish their activity before facilitating people to properly control their blood sugar levels
In tests in diabetic pigs, the non -human animal model rather similar to us, it was found that this new formulation of insulin reached 90 percent of its maximum activity within five minutes after insulin injection.
As a comparison, fast -acting commercial insulin began to show a significant activity only after ten minutes.In addition, the activity of monomeric insulin reached its maximum point at ten minutes, while commercial insulin required 25 minutes.In humans, this difference could be translated into a decrease in the four -way the time it takes for insulin to achieve its maximum activity.
"It is not preceded," says Appel, in statements cited by Scitechdaily."This has been an important objective for many large pharmaceutical companies for decades."
Monomeric insulin also ended its action before.The fact of starting and finishing the activity before facilitates people to use insulin in coordination with meal glucose levels to properly control their blood sugar levels.
Since its insulin formulation is activated so quickly, and, therefore, it is more similar to the insulin of a person without diabetes, researchers are excited about the possibility of contributing to the development of an artificial device for the pancreasthat works without the need for the patient to intervene at meals.
Source: Link
12/06/2023 10:09 a.m.
It's a little scared if one puts high doses, I don't know, if in 5 min acts and 10 min is a maximum peak, safe hypos.We will have to wait for results in humans.
12/06/2023 1:15 p.m.
Lada enero 2015.
Uso Toujeo y Novorapid.
I think it will be an advantage, I often find myself correcting the hyper and waiting (hours) for insulin to make its "magic."
If they give me to choose, I will be more than willIt is necessary in a relatively short time space, which seems to me a brutal advantage.
12/06/2023 3:48 p.m.
@fer - Diabetes Tipo 1 desde 1.998 | FreeStyle Libre 3 | Ypsomed mylife YpsoPump + CamAPS FX | Sin complicaciones. Miembro del equipo de moderación del foro.
Co-Autor de Vivir con Diabetes: El poder de la comunidad online, parte de los ingresos se destinan a financiar el foro de diabetes y mantener la comunidad online activa.
Well, it would seem an advance, and for those who have a bomb even more.
I did not believe that it was possible to make an insulin that had the beak in 5 minutes without clicking in vein.
Although we keep in mind that animal metabolism is usually faster than the human.
Does anyone know how long it takes to pass, since it is investigated in pigs, to market new insulins in humans?
12/06/2023 4:18 p.m.
En 1922 descubrieron la insulina, en 1930 la insulina lenta. ¿Que c*** han hecho desde entonces?
Well, without wanting to discourage anyone, here is my answer.
The marketing process of a new drug, as new insulins, from successful animals in animals to regular use in humans, usually includes several key stages:
1. Preclinical research: After success in animal tests, preclinical research continues to evaluate the safety and efficacy of the drug.This process can last several years.
2. New drug research application (IND): Before starting the human trials, an IND is submitted to the regulatory authorities (such as the FDA in the USA.).IND includes results of preclinical tests and plans for clinical trials.
3. Clinical trials Phase I: Small doses of medication are tested in a small group of people (20-80) to evaluate their adequate safety, dosage and side effects.
4. Clinical trials Phase II: It is done in a larger group of people (100-300) to evaluate efficiency and continue evaluating security.
5. Clinical trials Phase III: It is done in an even greater group of people (1,000-3,000) to confirm efficacy, monitor side effects, compare with standard treatments and collect information that allows the safe use of the medication.
6. Approval request for a new drug (NDA): After positive results of phase III, a NDA is presented to the regulatory authorities, including all the information about the drug.
7. Regulatory review and approval: The regulatory authority reviews the NDA, which can take from six months to several years, depending on several factors, including the complexity of the medication and the urgency of the need.
8. Marketing and phase IV: Once approved, the medicine is marketed.Phase IV implies post-commercialization studies to monitor long-term efficacy and safety.
In total, the process from successful tests in animals to commercialization can take between 10 and 15 years, although this may vary depending on multiple factors, including the urgency of the need of the drug, the efficiency of clinical trials, and the speedof the regulatory processes.In the case of new insulins, this process can be faster if it is modifications of existing insulins compared to completely new types of insulin.
12/06/2023 6:37 p.m.
@fer - Diabetes Tipo 1 desde 1.998 | FreeStyle Libre 3 | Ypsomed mylife YpsoPump + CamAPS FX | Sin complicaciones. Miembro del equipo de moderación del foro.
Co-Autor de Vivir con Diabetes: El poder de la comunidad online, parte de los ingresos se destinan a financiar el foro de diabetes y mantener la comunidad online activa.
If something showed us the pandemic is that this whole process, if you want, can be shortened enough ...
Who does not remember the competition between the Farmas to get the famous vaccine for the Covid?
Come on, what is a matter of priorities and focus, like most things in life !!!
12/06/2023 6:40 p.m.
@fer - Diabetes Tipo 1 desde 1.998 | FreeStyle Libre 3 | Ypsomed mylife YpsoPump + CamAPS FX | Sin complicaciones. Miembro del equipo de moderación del foro.
Co-Autor de Vivir con Diabetes: El poder de la comunidad online, parte de los ingresos se destinan a financiar el foro de diabetes y mantener la comunidad online activa.
Buffff, it seems to me a dream that we could have such a tool to correct instantly ...
12/08/2023 1:25 a.m.