Celiac disease and type 1 diabetes are related

The scientists - among which are Deborah Smyth, from the University of Cambridge, England -studied the DNA of more than 22,000 Europeans, including 8,000 type 1 diabetes and 2560 patients with celiac disease. Smyth's team focused on some linked genes linkedto the variants of type 1 diabetes and other variants of genes linked to celiac disease.The objective is to see if any of the gene variants overlap between the two diseases. The results: four variants of the celiac disease are linked to type 1 diabetes, and two variants of type 1 diabetes were linked to celiac disease.

These variants do not always behave in the same way.Some of both celiac disease and type 1 diabetes is more likely.But there were other opposite effects, making a more likely and less likely condition of the disease, such as the two sides of the same currency. ”One can begin to imagine how their combinations can lead to celiac disease and other combinations,They lead to type 1 diabetes, with multiple possible combinations of both diseases, ”writes editorialist Robert Flenge, PHD, of the Rheumatology Division of Brigham and Women's Boston Hospital.

Celiac disease and type 1 diabetes are two autoimmune diseases, and full writes that for years, epidemiological data have suggested a "common cause" between the two conditions. The new study shows the genetic overlap between celiac disease and type 1 diabetes.

Smyth and his team of researchers conducted new studies to prove the hypothesis that cereals and gluten can be an environmental factor in type 1 diabetes, which leads to an alteration of the function of the intestines of the immune system and their relationship withThe pancreas immune system. ”Smyth's study does not demonstrate the gluten hypothesis.Flege points out that "a combination of alleles (together with environmental and opportunity factors) leads to celiac disease, and others lead to type 1 diabetes" and also collect patterns "should lead to new knowledge in the disease."