Can Ozempic be used or similar for type 1 diabetes?

Today I bring a news about two medications that we so far knew for use in type 2 diabetes: the semaglutida and the tirzepatida .

Although these drugs are approved for type 2 diabetes and weight loss, new research proposes that they could also be effective in people with type 1 diabetes (T1D) who live overweight or obesity.

These medications, which help control blood sugar in type 2 diabetes, are being increasingly prescribed to people with T1D who have difficulty controlling their glucose due to insulin resistance, a common problem in overweight people.

According to Dr. Janet Snell-Bergeon, leader of the study, these medications could offer great benefits to patients with type 1 diabetes, although there are still few data on their effectiveness in this group.

The study reviewed the medical records of 100 adults with T1D that took semaglutida or tirzepatida, and the results were quite encouraging.

Those who took these medications experienced significant weight loss compared to controls (people who did not take these drugs).In addition, its blood sugar control improved similarly between the two groups.

- 77 % of those who took semaglutida and 93 % of those who took tirzepatida ** lost at least 5 % of their body weight **.
- 47 % of semaglutida users and 87 % of those of Tirzepatida ** lost at least 10 % of their weight **.

In addition, patients who took Tirzepatida reduced their need for insulin by 18 % on average, indicating that they improved their insulin resistance.

Although the results are very promising, Dr. Snell-Bergeon emphasizes that larger studies are still needed to confirm the safety and effectiveness of these medications in people with type 1 diabetes.

But without a doubt, these results suggest that the semaglutida and the tirzepatida could be an additional complement to the treatment of T1D, especially for those who fight with weight control.

What do you think of these advances?

Greetings,

Source: [EASD] (https:/5

I wish!Because DT1 also have insulin resistance, especially women.

Precisely about this I was thinking the other day.Since I have been a mother, it costs me much more to control glucose and I need more and more slow ... a fucking fucking, go

Hello, I am type 1 diabic (lada) and I have overweight.I was medicated with insulin from the beginning and still managed to lose some weight the 1st year (my BMI was 32).I consulted with my DRA and told me the Ozempic almost 2 years ago, the 1st year I dropped from 10 kg and in this about 5 more.I had to lower my slow insulin, just now I am using almost what I used.I clarify that I use Ozempic 0.50 that is the one that is prescribed for DBT2 not the one that is to lose weight.The drug is very expensive but luckily my social work covers, it is not magical we must take care of ourselves and move equally but it was a great help for me, my BMI is already in 28 and I got overweight.My cardiology says it has many additional heart protective benefits, so it is highly recommended.I personally did not feel important side effects, it is very important to follow up on their doctors.Ah another important thing since I use it, my hiccups were very reduced.

Can ozempic be used with an insulin pump?What percentage do you lower your basal rate as a percentage?I have heard that it can cause nausea and vomiting, which could be a very bad thing.Needed to lose weight the pump generally produces overweight.Thank you

Hello @android78xp

I think the pump thing doesn't make sense, since Ozempic is injected once a month, while the pump injects insulin constantly, so it doesn't seem to me to make much sense, since 1 injection a month is much better than carrying something with you all the time.

Greetings,

I don't understand how they talk about insulin-dependent Db1, I use a pump and I wanted to use ozempic for my overweight

fer said:
@fer said:

Hello@android78xp

I think the pump thing doesn't make sense, since Ozempic is injected once a month, while the pump injects insulin constantly, so it doesn't seem to me to make much sense, since 1 injection a month is much better than carrying something with you all the time.

Greetings,

Hello @android78xp, sorry, I think I didn't understand you correctly, what you are saying is that you have type 1 diabetes and that you use the insulin pump with FIASP or NovoRapid, or another... and that if it is possible in addition to that, use the Ozempic, correct?

If so, I couldn't tell you, maybe someone here has already had the experience and can tell us.

What I see for sure is that you validate the possible treatment with your Endocrine, it seems especially relevant to me when we talk about using medications or making changes to our medication regimen.

Well, the title of the post seemed clear.He sought experience from others like me.

fer said:
@fer said:

Hello good@android78xpSorry, I think I didn't understand you correctly, what you are saying is that you have type 1 diabetes and that you use the insulin pump with FIASP or NovoRapid, or another... and that if it is possible in addition to that, use the Ozempic, correct?

If so, I couldn't tell you, maybe someone here has already had the experience and can tell us.

What I see for sure is that you validate the possible treatment with your Endocrine, it seems especially relevant to me when we talk about using medications or making changes to our medication regimen.

You are right @android78xp, I misinterpreted your question.😊

Yes, the question was whether someone with type 1 diabetes who uses an insulin pump has also used Ozempic or a similar medication to help with being overweight.

In fact, from what is being seen in some studies and patient experiences, there are people with DM1 who use it (always under the supervision of their endocrinologist), especially when they are overweight, obese or insulin resistant.In some cases they report a reduction in insulin needs and significant weight loss.

Let's see if someone on the forum who is using it with a pump can share their real experience: how they adjusted their basal rates, if they had nausea at first, how it affected their blood glucose levels, and what results they obtained.

Surely it can be of great help to those of you who are considering this option.

Greetings,

Hello everyone

On this issue of semaglutide-tirzepatide, I can personally say that I have had a very good response to the treatment with my pump and both the weight loss and the reduction in insulin, it is a shame that they are not subsidized, at least in certain patients...

Greetings

Ruthbia said:
@Ruthbia said:

I wish!because T1Ds also have insulin resistance, especially women.

Good afternoon, in case it helps you, after many years with pens, as I have mentioned, I requested the change to Bomba when the algorithm was implemented.There were several reasons why I decided to change and one of them was Tresiba, since I do sports daily, the hypoglycemia with Tresiba at midday is terrible, what it took me to gain weight, between I entered the circle, more weight, more insulin, more insulin, more weight, so as not to get longer My endocrinologist put me on treatment with Tirzepatide, in three months I lost 20 kilos, my sensitivity to insulin increased a lot, so with sports, tirzepatide and the pump my needsInsulin levels have decreased greatly, I remain slim, my time in range is around 93-96% and the amount of daily insulin is almost 20% less.

It is a matter of time before it is approved in Type 1 Diabetes.

Ypso23 said:
@Ypso23 dijo:

Buenas tardes, por si les sirve de ayuda, después de muchos años con plumas, como ya he mencionado, solicité el cambio a Bomba cuando se implementó el algoritmo. Hubo varias razones por las que decidí cambiar y una de ellas fue Tresiba, ya que hago deporte a diario, la hipoglucemia con Tresiba al mediodía es terrible, lo que me hizo engordar, entretanto entré en el círculo, más peso, más insulina, más insulina, más peso, para no engordar más. Mi endocrinólogo me puso en tratamiento con Tirzepatida, en tres meses perdí 20 kilos, mi sensibilidad a la insulina aumentó mucho, así que con el deporte, la tirzepatida y la bomba mis necesidades de niveles de insulina han disminuido mucho, sigo delgada, mi tiempo en rango es de alrededor del 93-96% y la cantidad de insulina diaria es casi un 20% menor.

Es cuestión de tiempo que se apruebe para la diabetes tipo 1.

These medications, no matter how much they repeat them, are not for diabetes.They are for losing weight (less kg, less insulin you need).How do they work?From the experience of a colleague I tell you that what they do is make you sick, it makes your stomach turn.

I'm a little hard on the subject of weight, I suppose because I've been calculating portions and watching what I ate since I was a child.

I don't think taking a medication that will make you sick is the solution to obesity.It must be treated more from a psychological point of view than a physical one.Otherwise, as soon as you let this thing prick you, you'll gain weight again.

At no time did he state that these medications are approved for type I diabetes, clinical trials are being carried out in type I diabetes, but at the moment they have no indication. I would like to clarify that the decision to use Tirzepatide was made by my Endocrina because what he was really looking for was for me to lose weight.
Regarding the side effects of the treatment, fortunately I have not felt like that colleague you mentioned nor have I felt bad or had my stomach turn.
Regarding being strict with food, counting portions, etc. I want to think that the vast majority of diabetics are, unfortunately weight gain is not only due to eating poorly, in my case I think I clarified that it was the treatment with Tresiba that made me use a lot of glucose to treat multiple daily hypoglycemias and that led me to gain a lot of weight
Finally, after stopping tirzepatide and not having the medication that caused hypoglycemia, my weight has not changed one gram, so once again we can say that each patient is different.
Lastly, and to make it clear, the treatment decision must be made by the Endocrinologist.

At no point did I say that these medications are approved for people with type 1 diabetes. Clinical trials are currently being conducted in type 1 diabetes, but for now they are not approved for this indication.

I would also like to clarify that the decision to prescribe me tirzepatide was made by my endocrinologist, since the goal was indeed to help me lose weight.

As for the side effects, fortunately my experience has been very different from that of the colleague you mention. I have not felt sick nor has it caused me an upset stomach.

Regarding being strict with food and counting carbohydrates, I would like to think that the vast majority of people with diabetes are. Unfortunately, weight gain is not always the result of poor eating habits. In my case, as I explained, it was my treatment with Tresiba that caused me to suffer multiple episodes of hypoglycemia each day, forcing me to consume large amounts of glucose to correct them. That is what led to my weight gain.

Finally, after stopping tirzepatide and not continuing the treatment that was causing my hypoglycemia, my weight has not changed one gram. Once again, this shows that each patient is different.

And to make one last note absolutely clear: the decision to start or stop this type of treatment should always be made by an endocrinologist.