How to predict diabetes, 10 years before it appears
03/24/2011 3:05 p.m.
Scientists in the United States developed a test that can identify people at risk of contracting type 2 diabetes a decade before the symptoms appear.
The analysis detects the levels of five molecules in the blood which predict who is at risk of developing the disease.
The scientists of the Massachusetts General Hospital said in the journal Nature Medicine that the early detection of type 2 diabetes could eventually help prevent complications associated with the disease, such as blindness.
"This finding can offer information on metabolic routes that are altered early in the process that leads to diabetes," says Dr. Thomas Wang, who directed the study.
According to the researcher, the test not only detects the risk of type 2 diabetes among the general population, but also among the people who present the risk factors associated with the disease, such as obesity.
Studies in the past had found high levels of certain amino acids in obese individuals or people who have insulin resistance.Both disorders precede the development of type 2 diabetes.
Massachusetts scientists wanted to investigate whether these levels of amino acids or other blood molecules could be used to predict the future appearance of type 2 diabetes in individuals who were healthy.
Early diagnosis
The researchers followed 2,422 healthy individuals, of which 201 developed diabetes 2 in the next 12 years of the study.
The scientists measured the levels of 61 metabolites in 189 of the participants who developed the disease and 189 that were free from the disorder.
Metabolites are small molecules that occur in the organism's metabolic processes and are released into the bloodstream.
The results showed that the increase in five amino acids were "significantly" associated with the future development of type 2 diabetes.
The scientists found that individuals with the highest levels of these blood compounds showed five times more likely to develop the disease for the next 12 years.
As type 2 diabetes is the culmination of the organism's inability to metabolize glucose, scientists believe that the possibility of detecting the interruption of this metabolic process in such an early stage could significantly reduce the incidence of the disease.
As Dr. Robert Gerszten points out, another of the researchers, "now they will need to carry out more studies to confirm whether these metabolites play a role in the process that leads to diabetes and if there is a way that we can stop the damage".
For her part, Dr. Victoria King, head of research of the Diabetes UK organization, states that "early diagnosis and effective control of type 2 diabetes are crucial to reduce the risk of developing complications, such as heart disease, stroke, insufficiency, insufficiencyrenal, blindness and amputation. "
"Therefore, it is very important to find a way to identify those who are at risk of developing the disease."
"This study, in the future, could lead to ways to help us identify them at risk in addition to offering new information about how and why type 2 diabetes develops," adds the expert.
03/24/2011 3:05 p.m.
@fer - Diabetes Tipo 1 desde 1.998 | FreeStyle Libre 3 | Ypsomed mylife YpsoPump + CamAPS FX | Sin complicaciones. Miembro del equipo de moderación del foro.
Co-Autor de Vivir con Diabetes: El poder de la comunidad online, parte de los ingresos se destinan a financiar el foro de diabetes y mantener la comunidad online activa.
Type I have us abandoned:-/
03/25/2011 3:18 p.m.
Apparently, we are a lost case!;) :)) :)) :))
I suppose that predicting a type 1 is much more complicated, for the short time in which it manifests and the way it does, however, type 2 has a component that depends on the eating habits, lifestyle, etc.... and manifests itself in a more progressive way.
Greetings,
03/26/2011 3:58 a.m.
@fer - Diabetes Tipo 1 desde 1.998 | FreeStyle Libre 3 | Ypsomed mylife YpsoPump + CamAPS FX | Sin complicaciones. Miembro del equipo de moderación del foro.
Co-Autor de Vivir con Diabetes: El poder de la comunidad online, parte de los ingresos se destinan a financiar el foro de diabetes y mantener la comunidad online activa.
The truth is that lately the numerous advances in pharmacology and studies for type 2 lead to that thought ... more than once I have released the same to my endo: that they have us forgotten !!!
We are not a rare disease because it is considered rare less than 5 per 10,000, and type one diabetes must be something like 1 in 120, so it is likely that it will be very investigated, even with few significant advances.Let's not forget that insulin has not yet turned 100 years ... that in Spain it has not been 80 years, and that basal insulins barely reach dozen years.
In 36 -hour basal insulin years, the possible vaccine for type 1 diabetes, continuous non -invasive meters or artificial pancreas (closed handle bomb) can change our disease a lot.
Of course "next years" can mean, 15 or 20 years ...: (((((
03/26/2011 7:57 a.m.
Owash Will the 36 -hour basal take so long to arrive?What is known about her?
03/26/2011 9:35 a.m.
Hija de 35 años , diabética desde los 5. Glico: normalmente de 6 , pero 6,7 la última ( 6,2 marcaba el Free)
Fiasp: 4- 4- 3 Toujeo: 20
I have already read a post of yours 6 months ago, where you talk about the swallow, which is in the last test phase and put 3 times a week.Let's see if it comes soon: D
03/26/2011 5:02 p.m.
Hija de 35 años , diabética desde los 5. Glico: normalmente de 6 , pero 6,7 la última ( 6,2 marcaba el Free)
Fiasp: 4- 4- 3 Toujeo: 20
God hears you Owash ...
03/26/2011 5:46 p.m.
Well, I don't think that insulin is marketed in Spain before 2-3 years.
It is still in phase 3 (replicate studies in different places) and at the moment only in type 2.
Then it will happen to type 1, which will not happen before 5 years, I suppose.
03/27/2011 5:41 a.m.
Joer, I had no idea of that 36 -hour basal insulin.With that and a non -invasive meter would be the pump; P
03/27/2011 8:48 a.m.