New hopeful scientific discovery

The digital newspaper "20minutos", publishes today, April 26, very interesting information, about the discovery of new cells that can effectively activate the pancreas.
We must not lose hope, it is good to keep some illusion, especially for minors.
Greetings.

The digital newspaper "20minutos", publishes today, April 26, very interesting information, about the discovery of new cells that can effectively activate the pancreas.
We must not lose hope, it is good to keep some illusion, especially for minors.
Greetings.

You refer to this:

A hormone that stimulates insulin production offers more hope to diabetics

■ Harvard researchers discover a hormone, Betatrophin, which stimulates production cells pancreatic insulin secretors.
■ These cells produce insulin at speeds up to 30 times the normal rate and believe it can be a more effective diabetes potential therapy.
■ For patients it would mean "managing an injection of this hormone, once a week, per month or even a year," according to researchers.

Researchers from the Harvard stem cell Institute (HSCI), in Cambridge, Massachusetts (United States), have discovered a hormone, Betatrophin, which causes mice to produce pancreatic cells insulin secretorys at speeds of up to 30 times the normal rate.Thus, scientists believe that it can be a radically more effective therapy against type 2 diabetes and that could also act in treatment against type 1 diabetes.

They have already attracted the attention of drug manufacturers These new beta cells produce insulin only when the body is requested, offering the possibility of a natural insulin regulation and a great reduction in complications associated with diabetes, the main cause ofMedical amputations and non -genetic loss of vision, according to the results of the research, published Thursday in the online edition of Cell magazine and scheduled for its printed edition of May 9.

The researchers who discovered Betatrophin, Hsci Doug Melton's co -director and the Peng Yi postdoctoral fellowship warn that there is still a lot of work to do before being able to be used as a human treatment.However, the results of his work, which was largely supported by a federal research scholarship, have already attracted the attention of medication manufacturers.

Hope for diabetics

"If this could be used in people, it could eventually mean that, instead of putting insulin injections three times a day, it is possible to administer an injection of this hormone, once a week or once a month or in theBetter cases may even once a year, "said Melton, a professor at Harvard University and co -director of the Department of stem cells and regenerative biology of the University Center.

There is a lot of work to be done before being used as a treatment in humans type 2 diabetes, a disease associated with the national obesity epidemic, is generally caused by a combination of excess weight and lack of exercise and makes patients slowly losebeta cells and the ability to produce adequate insulin."Our idea is relatively simple: We would likeReplication of beta cells, "says Melton.

Although melton sees Betatrophin mainly as a treatment for type 2 diabetes, he believes that he could play a role in the treatment of type 1 diabetes, so that, perhaps increases the number of beta cells and slows down the progression of this autoimmune diseaseWhen it is diagnosed for the first time.

The work with the Technology Development Office of Harvard University, Melton and YiThey already have a collaboration agreement with Evotec, a German biotechnology company that now has 15 scientists who work in the development of Betatrophin, a compound that has been authorized for Janssen Pharmaceuticals, a Johnson & AMP company;Johnson.

A blow of luck
As is the case in the investigation of basic science, chance played an important role in Betatrophin's discovery, which melton and yi originally called Rabbit because they discovered it during the Chinese year of the rabbit and because it makes beta cells multiplyquickly.

For more than 15 years, the main objective of Melton's work has been type 2 diabetes, but also the least common type 1 or youth diabetes, in which he began to focus when his son was diagnosed with her when he was a baby and, later, she was also diagnosed in her daughter.In addition, most of Melton's work has involved the use of stem cells, although they did not play any direct role in Betatrophin's discovery.

I would like to say that this discovery came from deep thought, but it was more a little luck "I would like to say that this discovery came from deep thought and we knew we were going to find this, but it was more a little luck," said Melton, explained Melton, explainedwho in addition to his functions in Harvard works at the 'Howard Hughes Medical Institute' (United States)."We wondered what happens when an animal does not have enough insulin. We were lucky to find this new gene that had almost unnoticed before," he added.

"Another suggestion came from studying something that people know but not much: what happens during pregnancy. When a woman becomes pregnant, her carbohydrate load, her call to insulin, can increase a huge amount due to needsWeight and fetus nutrition.", he says.

Melton and Yi have been working on the project for more than four years, but the great advance occurred on February 10, 2011. "He was sitting there in the microscope in search of all these replicating beta cells," said Yi-, and barelyI could believe what I saw.At first I was not sure whether repeating the experiment or telling me to melton immediately, but he opted for the second: "I showed him the image and told him that it is a secret protein, so I was very excited about the result," recalls Yi

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Well, thanks for publishing the entire news and the link, they can read the full text all the foreros.