Researchers at the University of Cádiz have found a harmful synergistic effect between dementia, more specifically that related to Alzheimer, and diabetes.
María del Carmen Infante García, Mónica García Alloza and Juan José Ramos Rodríguez, from the University of Cádiz.(DM)
Researchers at the University of Cádiz (UCA) have proven how the concomitant presence of type 2 diabetes and Alzheimer's disease is a worsening of both metabolic pathology and central complications.
"In the long term, since these are two chronic pathologies, we have not observed a stabilization, but the synergistic effect is maintained, manifested in observed brain atrophy, Tau pathology, central inflammatory process or neuronal and synaptic alterations, as well as inThe learning and memory processes, "Mónica García-Alloza, from the Physiology Area of the UCA School of Medicine, has detailed medical newspaper.
In previous studies this group had already proven the synergistic effect between different metabolic problems and alzheimer's or vascular dementia.For this work, published in Psychoneuroendocrinology, "we have worked with different murine models, specifically we have created a mouse fruit of the crossing of two classic models, one of type 2 diabetes (db/db mouse) and another of Alzheimer's disease (Appswe mouse/PS1de9.
The learning and memory of these animals has been valued, as well as the metabolic and central pathology associated with alzheimer's and vascular dementia: amyloid pathology, tau, synaptic loss or spontaneous bleeding, "he explained.
dual sense
The creation of these models has allowed studying the relationship between dementia and diabetes in different stages of evolution, achieving a very complete study in which it is shown that the conversation between Alzheimer's and Diabetes is double meaning.Having Alzheimer worsens metabolic characteristics and, in the same way, having metabolic alterations has consequences at the central nervous system level.
This group, whose line of work is focused on analyzing the different types of diabetes and determining to what degree they affect and/or aggravate the situation of the central nervous system favoring the development of dementia, intends to continue working on the role of metabolic alterations in stagesPrecocos, when strict control of them is still possible, and check their role at the central level exploring different therapeutic alternatives to at least slow the negative effects of these pathologies.
